Nature Communications (May 2016)

Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition

  • Hyung-Joon Kwon,
  • Go-Eun Choi,
  • Sangryeol Ryu,
  • Soon Jae Kwon,
  • Sun Chang Kim,
  • Claire Booth,
  • Kim E. Nichols,
  • Hun Sik Kim

DOI
https://doi.org/10.1038/ncomms11686
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

Read online

NK cell activation requires multiple signals. Here the authors show that while NKG2D, 2B4, or DNAM-1 receptor activation is insufficient to induce cytokine production, these signals synergize by Vav-1-mediated NF-κB multiphosphorylation, and this signaling checkpoint is defective in X-linked lymphoproliferative disease.