Advances in Human Biology (Jan 2021)
Evaluation of efficacy of platelet-rich fibrin for papilla reconstruction
Abstract
Introduction: Blood clot or platelet concentrates have been used as a scaffold for regeneration of lost tissues. The most difficult case to date is the restoration of missing interdental papillae in the anterior maxillary area. Hence, the aim of the study is to evaluate the efficacy of the use of platelet-rich fibrin (PRF) membrane in the treatment of black triangles and regeneration of interdental papilla. Materials and Methods: A non-randomised, single-arm study was carried out. Each participant had undergone an initial periodontal diagnosis, including oral hygiene instructions, plaque control and scaling and root planing. All clinical recordings were recorded immediately before surgery (baseline), 1 week, 4-week and after 12-week intervals following periodontal surgery. The measurements recorded were triangle height (TH), triangle width (TW), Papilla Presence Index (PPI) and percentage fill. The split-thickness flap was carried via the semilunar incision, creating a pouch. PRF was obtained using a standard protocol, which was inserted into the pouch allowing interdental papillae to be filled. The periodontal dressing was given for 7 days. The observations were recorded after 1 week, 49 weeks and 12 weeks of surgery. For descriptive analysis, mean ± standard deviation SD at baseline, 1 week, 4 weeks and 12 weeks was calculated, and for non-parametric test, Friedman and Chi-square tests were used. Results: Clinical parameters such as TH, TW and PPI (mm) was 3.96, 3.86 and 3.82 at baseline which after 12 weeks got reduced to 1.36, 1.68 and 1.58, respectively. This reduction in TH, TW and PPI(mm) was statistically significant (P< 0.001). Percentage fill in black triangle area was about 85% after 12-week follow-up. Conclusion: PRF membrane is effective in treating black triangles and regeneration of interdental papilla and can be used successfully.
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