Arquivos de Neuro-Psiquiatria (Jun 1984)

Immunological disturbance in West and Lennox-Gastaut syndromes

  • Terezinha C. B. Montelli,
  • Norma G. S. Mota,
  • M. Terezinha S. Peraçoli,
  • Elza A. Torres,
  • M. Thereza Rezkallah-Iwasso

DOI
https://doi.org/10.1590/S0004-282X1984000200005
Journal volume & issue
Vol. 42, no. 2
pp. 132 – 139

Abstract

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Cell-mediated and humoral immunity were investigated in 18 patients with West syndrome, 12 with Lennox-Gastaut syndrome and 19 healthy controls. The study included determination of Ô and  peripheral blood lymphocytes, serum levels of IgG, IgA and IgM, skin sensibilization with DNCB, intracutaneous PHA, leucocyte migration inhibition test and lymphocyte blastic transformation in the presence of PHA. Cell-mediated deficiency was detected in 28 children whereas low levels of immunoglobulins were observed only in 6 children. Immunological disturbances were more prominent in children with West syndrome.