EMBO Molecular Medicine (Oct 2021)
A microRNA signature that correlates with cognition and is a target against cognitive decline
- Md Rezaul Islam,
- Lalit Kaurani,
- Tea Berulava,
- Urs Heilbronner,
- Monika Budde,
- Tonatiuh Pena Centeno,
- Vakthang Elerdashvili,
- Maria‐Patapia Zafieriou,
- Eva Benito,
- Sinem M Sertel,
- Maria Goldberg,
- Fanny Senner,
- Janos L Kalman,
- Susanne Burkhardt,
- Anne Sophie Oepen,
- Mohammad Sadman Sakib,
- Cemil Kerimoglu,
- Oliver Wirths,
- Heike Bickeböller,
- Claudia Bartels,
- Frederic Brosseron,
- Katharina Buerger,
- Nicoleta‐Carmen Cosma,
- Klaus Fliessbach,
- Michael T. Heneka,
- Daniel Janowitz,
- Ingo Kilimann,
- Luca Kleinedam,
- Christoph Laske,
- Coraline D Metzger,
- Matthias H Munk,
- Robert Perneczky,
- Oliver Peters,
- Josef Priller,
- Boris S. Rauchmann,
- Nina Roy,
- Anja Schneider,
- Annika Spottke,
- Eike J Spruth,
- Stefan Teipel,
- Maike Tscheuschler,
- Michael Wagner,
- Jens Wiltfang,
- Emrah Düzel,
- Frank Jessen,
- Delcode Study Group,
- Silvio O Rizzoli,
- Wolfram‐Hubertus Zimmermann,
- Thomas G Schulze,
- Peter Falkai,
- Farahnaz Sananbenesi,
- Andre Fischer
Affiliations
- Md Rezaul Islam
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Lalit Kaurani
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Tea Berulava
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Urs Heilbronner
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig‐Maximilians‐University Munich
- Monika Budde
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig‐Maximilians‐University Munich
- Tonatiuh Pena Centeno
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Vakthang Elerdashvili
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Maria‐Patapia Zafieriou
- Institute of Pharmacology and Toxicology, University Medical Center Göttingen
- Eva Benito
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Sinem M Sertel
- Department of Neuro‐ and Sensory Physiology, University Medical Center Göttingen
- Maria Goldberg
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Fanny Senner
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig‐Maximilians‐University Munich
- Janos L Kalman
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig‐Maximilians‐University Munich
- Susanne Burkhardt
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Anne Sophie Oepen
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Mohammad Sadman Sakib
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Cemil Kerimoglu
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- Oliver Wirths
- Department for Psychiatry and Psychotherapy, University Medical Center Göttingen
- Heike Bickeböller
- Department of Genetic Epidemiology, University Medical Center Göttingen
- Claudia Bartels
- Department for Psychiatry and Psychotherapy, University Medical Center Göttingen
- Frederic Brosseron
- German Center for Neurodegenerative Diseases
- Katharina Buerger
- German Center for Neurodegenerative Diseases (DZNE, Munich)
- Nicoleta‐Carmen Cosma
- Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin
- Klaus Fliessbach
- German Center for Neurodegenerative Diseases
- Michael T. Heneka
- German Center for Neurodegenerative Diseases
- Daniel Janowitz
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich
- Ingo Kilimann
- German Center for Neurodegenerative Diseases (DZNE)
- Luca Kleinedam
- German Center for Neurodegenerative Diseases
- Christoph Laske
- Department of Psychosomatic Medicine, Rostock University Medical Center
- Coraline D Metzger
- German Center for Neurodegenerative Diseases (DZNE)
- Matthias H Munk
- Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen
- Robert Perneczky
- Department of Psychiatry and Psychotherapy, Ludwig‐Maximilians‐University Munich
- Oliver Peters
- Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin
- Josef Priller
- German Center for Neurodegenerative Diseases (DZNE)
- Boris S. Rauchmann
- Department of Psychiatry and Psychotherapy, Ludwig‐Maximilians‐University Munich
- Nina Roy
- German Center for Neurodegenerative Diseases
- Anja Schneider
- German Center for Neurodegenerative Diseases
- Annika Spottke
- German Center for Neurodegenerative Diseases
- Eike J Spruth
- German Center for Neurodegenerative Diseases (DZNE)
- Stefan Teipel
- German Center for Neurodegenerative Diseases (DZNE)
- Maike Tscheuschler
- Department of Psychiatry, Medical Faculty, University of Cologne
- Michael Wagner
- German Center for Neurodegenerative Diseases
- Jens Wiltfang
- Department for Psychiatry and Psychotherapy, University Medical Center Göttingen
- Emrah Düzel
- German Center for Neurodegenerative Diseases (DZNE)
- Frank Jessen
- German Center for Neurodegenerative Diseases
- Delcode Study Group
- Silvio O Rizzoli
- Department of Neuro‐ and Sensory Physiology, University Medical Center Göttingen
- Wolfram‐Hubertus Zimmermann
- Institute of Pharmacology and Toxicology, University Medical Center Göttingen
- Thomas G Schulze
- Department for Psychiatry and Psychotherapy, University Medical Center Göttingen
- Peter Falkai
- Department of Psychiatry and Psychotherapy, Ludwig‐Maximilians‐University Munich
- Farahnaz Sananbenesi
- Department for Psychiatry and Psychotherapy, University Medical Center Göttingen
- Andre Fischer
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases
- DOI
- https://doi.org/10.15252/emmm.202013659
- Journal volume & issue
-
Vol. 13,
no. 11
pp. 1 – 28
Abstract
Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3‐microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics.
Keywords
