EMBO Molecular Medicine (Nov 2021)
A microRNA signature that correlates with cognition and is a target against cognitive decline
- Md Rezaul Islam,
- Lalit Kaurani,
- Tea Berulava,
- Urs Heilbronner,
- Monika Budde,
- Tonatiuh Pena Centeno,
- Vakthang Elerdashvili,
- Maria‐Patapia Zafieriou,
- Eva Benito,
- Sinem M Sertel,
- Maria Goldberg,
- Fanny Senner,
- Janos L Kalman,
- Susanne Burkhardt,
- Anne Sophie Oepen,
- Mohammad Sadman Sakib,
- Cemil Kerimoglu,
- Oliver Wirths,
- Heike Bickeböller,
- Claudia Bartels,
- Frederic Brosseron,
- Katharina Buerger,
- Nicoleta‐Carmen Cosma,
- Klaus Fliessbach,
- Michael T. Heneka,
- Daniel Janowitz,
- Ingo Kilimann,
- Luca Kleinedam,
- Christoph Laske,
- Coraline D Metzger,
- Matthias H Munk,
- Robert Perneczky,
- Oliver Peters,
- Josef Priller,
- Boris S. Rauchmann,
- Nina Roy,
- Anja Schneider,
- Annika Spottke,
- Eike J Spruth,
- Stefan Teipel,
- Maike Tscheuschler,
- Michael Wagner,
- Jens Wiltfang,
- Emrah Düzel,
- Frank Jessen,
- Delcode Study Group,
- Silvio O Rizzoli,
- Wolfram‐Hubertus Zimmermann,
- Thomas G Schulze,
- Peter Falkai,
- Farahnaz Sananbenesi,
- Andre Fischer
Affiliations
- Md Rezaul Islam
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Lalit Kaurani
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Tea Berulava
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Urs Heilbronner
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital Ludwig‐Maximilians‐University Munich Munich Germany
- Monika Budde
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital Ludwig‐Maximilians‐University Munich Munich Germany
- Tonatiuh Pena Centeno
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Vakthang Elerdashvili
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Maria‐Patapia Zafieriou
- Institute of Pharmacology and Toxicology University Medical Center Göttingen Göttingen Germany
- Eva Benito
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Sinem M Sertel
- Department of Neuro‐ and Sensory Physiology University Medical Center Göttingen Göttingen Germany
- Maria Goldberg
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Fanny Senner
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital Ludwig‐Maximilians‐University Munich Munich Germany
- Janos L Kalman
- Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital Ludwig‐Maximilians‐University Munich Munich Germany
- Susanne Burkhardt
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Anne Sophie Oepen
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Mohammad Sadman Sakib
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Cemil Kerimoglu
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- Oliver Wirths
- Department for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
- Heike Bickeböller
- Department of Genetic Epidemiology University Medical Center Göttingen Göttingen Germany
- Claudia Bartels
- Department for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
- Frederic Brosseron
- German Center for Neurodegenerative Diseases Bonn Germany
- Katharina Buerger
- German Center for Neurodegenerative Diseases (DZNE, Munich) Munich Germany
- Nicoleta‐Carmen Cosma
- Department of Psychiatry and Psychotherapy Charité – Universitätsmedizin Berlin Berlin Germany
- Klaus Fliessbach
- German Center for Neurodegenerative Diseases Bonn Germany
- Michael T. Heneka
- German Center for Neurodegenerative Diseases Bonn Germany
- Daniel Janowitz
- Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich Munich Germany
- Ingo Kilimann
- German Center for Neurodegenerative Diseases (DZNE) Rostock Germany
- Luca Kleinedam
- German Center for Neurodegenerative Diseases Bonn Germany
- Christoph Laske
- Department of Psychosomatic Medicine Rostock University Medical Center Rostock Germany
- Coraline D Metzger
- German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany
- Matthias H Munk
- Section for Dementia Research Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy University of Tübingen Tübingen Germany
- Robert Perneczky
- Department of Psychiatry and Psychotherapy Ludwig‐Maximilians‐University Munich München Germany
- Oliver Peters
- Department of Psychiatry and Psychotherapy Charité – Universitätsmedizin Berlin Berlin Germany
- Josef Priller
- German Center for Neurodegenerative Diseases (DZNE) Berlin Germany
- Boris S. Rauchmann
- Department of Psychiatry and Psychotherapy Ludwig‐Maximilians‐University Munich München Germany
- Nina Roy
- German Center for Neurodegenerative Diseases Bonn Germany
- Anja Schneider
- German Center for Neurodegenerative Diseases Bonn Germany
- Annika Spottke
- German Center for Neurodegenerative Diseases Bonn Germany
- Eike J Spruth
- German Center for Neurodegenerative Diseases (DZNE) Berlin Germany
- Stefan Teipel
- German Center for Neurodegenerative Diseases (DZNE) Rostock Germany
- Maike Tscheuschler
- Department of Psychiatry Medical Faculty University of Cologne Cologne Germany
- Michael Wagner
- German Center for Neurodegenerative Diseases Bonn Germany
- Jens Wiltfang
- Department for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
- Emrah Düzel
- German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany
- Frank Jessen
- German Center for Neurodegenerative Diseases Bonn Germany
- Delcode Study Group
- Silvio O Rizzoli
- Department of Neuro‐ and Sensory Physiology University Medical Center Göttingen Göttingen Germany
- Wolfram‐Hubertus Zimmermann
- Institute of Pharmacology and Toxicology University Medical Center Göttingen Göttingen Germany
- Thomas G Schulze
- Department for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
- Peter Falkai
- Department of Psychiatry and Psychotherapy Ludwig‐Maximilians‐University Munich München Germany
- Farahnaz Sananbenesi
- Department for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
- Andre Fischer
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases Göttingen Germany
- DOI
- https://doi.org/10.15252/emmm.202013659
- Journal volume & issue
-
Vol. 13,
no. 11
pp. n/a – n/a
Abstract
Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3‐microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics.
Keywords
