The Emerging Role of Histone Deacetylase Inhibitors in Cervical Cancer Therapy

Iason Psilopatis; Nikolaos Garmpis; Anna Garmpi; Kleio Vrettou; Panagiotis Sarantis; Evangelos Koustas; Efstathios A. Antoniou; Dimitrios Dimitroulis; Gregory Kouraklis; Michail V. Karamouzis; Georgios Marinos; Konstantinos Kontzoglou; Afroditi Nonni; Konstantinos Nikolettos; Florian N. Fleckenstein; Christina Zoumpouli; Christos Damaskos

doi:10.3390/cancers15082222

Cancers (Apr 2023)

The Emerging Role of Histone Deacetylase Inhibitors in Cervical Cancer Therapy

Iason Psilopatis,
Nikolaos Garmpis,
Anna Garmpi,
Kleio Vrettou,
Panagiotis Sarantis,
Evangelos Koustas,
Efstathios A. Antoniou,
Dimitrios Dimitroulis,
Gregory Kouraklis,
Michail V. Karamouzis,
Georgios Marinos,
Konstantinos Kontzoglou,
Afroditi Nonni,
Konstantinos Nikolettos,
Florian N. Fleckenstein,
Christina Zoumpouli,
Christos Damaskos

Affiliations

Iason Psilopatis: Department of Gynecology, Charité—Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Nikolaos Garmpis: Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Anna Garmpi: First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Kleio Vrettou: Department of Cytopathology, Sismanogleio General Hospital, 15126 Athens, Greece
Panagiotis Sarantis: Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Evangelos Koustas: Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Efstathios A. Antoniou: Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Dimitrios Dimitroulis: Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Gregory Kouraklis: Department of Surgery, Evgenideio Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Michail V. Karamouzis: Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Georgios Marinos: Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Konstantinos Kontzoglou: Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Afroditi Nonni: First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Konstantinos Nikolettos: Obstetric and Gynecologic Clinic, Medical School, Democritus University of Thrace, 68110 Alexandroupolis, Greece
Florian N. Fleckenstein: Department of Diagnostic and Interventional Radiology, Charité—Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Christina Zoumpouli: Department of Pathology, Sismanogleio General Hospital, 15126 Athens, Greece
Christos Damaskos: Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

DOI: https://doi.org/10.3390/cancers15082222
Journal volume & issue: Vol. 15, no. 8
p. 2222

Abstract

Read online

Cervical carcinoma is one of the most common cancers among women globally. Histone deacetylase inhibitors (HDACIs) constitute anticancer drugs that, by increasing the histone acetylation level in various cell types, induce differentiation, cell cycle arrest, and apoptosis. The aim of the current review is to study the role of HDACIs in the treatment of cervical cancer. A literature review was conducted using the MEDLINE and LIVIVO databases with a view to identifying relevant studies. By employing the search terms “histone deacetylase” and “cervical cancer”, we managed to identify 95 studies published between 2001 and 2023. The present work embodies the most up-to-date, comprehensive review of the literature centering on the particular role of HDACIs as treatment agents for cervical cancer. Both well-established and novel HDACIs seem to represent modern, efficacious anticancer drugs, which, alone or in combination with other treatments, may successfully inhibit cervical cancer cell growth, induce cell cycle arrest, and provoke apoptosis. In summary, histone deacetylases seem to represent promising future treatment targets in cervical cancer.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

About the journal

Abstract

Keywords