Bio-Hybrid Hydrogels Incorporated into a System of Salicylic Acid-pH/Thermosensitive Nanocarriers Intended for Cutaneous Wound-Healing Processes

Katarzyna Bialik-Wąs; Małgorzata Miastkowska; Paulina Sapuła; Klaudia Pluta; Dagmara Malina; Jarosław Chwastowski; Mateusz Barczewski

doi:10.3390/pharmaceutics14040773

Pharmaceutics (Apr 2022)

Bio-Hybrid Hydrogels Incorporated into a System of Salicylic Acid-pH/Thermosensitive Nanocarriers Intended for Cutaneous Wound-Healing Processes

Katarzyna Bialik-Wąs,
Małgorzata Miastkowska,
Paulina Sapuła,
Klaudia Pluta,
Dagmara Malina,
Jarosław Chwastowski,
Mateusz Barczewski

Affiliations

Katarzyna Bialik-Wąs: Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31155 Cracow, Poland
Małgorzata Miastkowska: Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31155 Cracow, Poland
Paulina Sapuła: Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31155 Cracow, Poland
Klaudia Pluta: Department of Chemical Technology and Environmental Analytics, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31155 Cracow, Poland
Dagmara Malina: Department of Chemical Technology and Environmental Analytics, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31155 Cracow, Poland
Jarosław Chwastowski: Department of Chemical Technology and Environmental Analytics, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31155 Cracow, Poland
Mateusz Barczewski: Institute of Materials Technology, Faculty of Mechanical Engineering and Management, Poznan University of Technology, 24 Jana Pawła II St., 60965 Poznan, Poland

DOI: https://doi.org/10.3390/pharmaceutics14040773
Journal volume & issue: Vol. 14, no. 4
p. 773

Abstract

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In this paper, the preparation method of bio-hybrid hydrogels incorporated into a system of salicylic acid-pH/thermosensitive nanocarriers to speed up the wound-healing process was developed. This combination creates a dual drug delivery system, which releases the model hydrophobic active substance—salicylic acid—in a gradual and controlled manner for an extended time. Our research team has determined the various properties of bio-hybrid hydrogels based on their physicochemical (swelling degree, and degradation), structural (FT-IR), morphological (SEM), and mechanical (elongation tests) traits. Moreover, empty pH/thermosensitive nanocarriers and their salicylic acid-containing systems were characterized using the following methods: DLS, TG/DTG, and DSC. Additionally, salicylic acid release profiles directly from thermosensitive nanocarriers were compared to the bio-hybrid matrix. These studies were conducted in PBS (pH = 7.4) for 7 days using the USP4 method. To evaluate the antibacterial properties of the obtained materials, the inhibition of growth of Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger—as the main microorganisms responsible for human infections—were tested. The obtained results indicated that the pH/thermosensitive nanocarrier–salicylic acid system and bio-hybrid hydrogels are characterized by antibacterial activity against both S. aureus and E. coli.

Published in Pharmaceutics

ISSN: 1999-4923 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceutics/

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