Nature Communications (Apr 2021)

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

  • David Baglietto-Vargas,
  • Stefania Forner,
  • Lena Cai,
  • Alessandra C. Martini,
  • Laura Trujillo-Estrada,
  • Vivek Swarup,
  • Marie Minh Thu Nguyen,
  • Kelly Do Huynh,
  • Dominic I. Javonillo,
  • Kristine Minh Tran,
  • Jimmy Phan,
  • Shan Jiang,
  • Enikö A. Kramár,
  • Cristina Nuñez-Diaz,
  • Gabriela Balderrama-Gutierrez,
  • Franklin Garcia,
  • Jessica Childs,
  • Carlos J. Rodriguez-Ortiz,
  • Juan Antonio Garcia-Leon,
  • Masashi Kitazawa,
  • Mohammad Shahnawaz,
  • Dina P. Matheos,
  • Xinyi Ma,
  • Celia Da Cunha,
  • Ken C. Walls,
  • Rahasson R. Ager,
  • Claudio Soto,
  • Antonia Gutierrez,
  • Ines Moreno-Gonzalez,
  • Ali Mortazavi,
  • Andrea J. Tenner,
  • Grant R. MacGregor,
  • Marcelo Wood,
  • Kim N. Green,
  • Frank M. LaFerla

DOI
https://doi.org/10.1038/s41467-021-22624-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some aspects of sporadic late onset AD.