Division of Cardiology, Department of Medicine, Institute of Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Montefiore University Hospital, New York, NY 10461, USA
Jessica Gambardella
Division of Cardiology, Department of Medicine, Institute of Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Montefiore University Hospital, New York, NY 10461, USA
Vanessa Castellanos
Division of Cardiology, Department of Medicine, Institute of Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Montefiore University Hospital, New York, NY 10461, USA
Valentina Trimarco
Department of Neuroscience, “Federico II” University, 80131 Naples, Italy
Gaetano Santulli
Division of Cardiology, Department of Medicine, Institute of Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Montefiore University Hospital, New York, NY 10461, USA
The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.
