USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

Abstract

BRCA1 ligase activity is tightly regulated to maintain genome stability and confer DNA double strand repair. Here the authors identify USP48 as a H2A deubiquitinating enzyme that acts as a BRCA1 E3 ligase antagonist and characterize its role during DNA repair.