Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis

Uday Tak; Terje Dokland; Michael Niederweis

doi:10.1038/s41467-020-20533-1

Nature Communications (Jan 2021)

Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis

Uday Tak,
Terje Dokland,
Michael Niederweis

Affiliations

Uday Tak: Department of Microbiology, University of Alabama at Birmingham
Terje Dokland: Department of Microbiology, University of Alabama at Birmingham
Michael Niederweis: Department of Microbiology, University of Alabama at Birmingham

DOI: https://doi.org/10.1038/s41467-020-20533-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Tuberculosis necrotizing toxin (TNT) is secreted by Mycobacterium tuberculosis to kill host cells. Here, Tak, Dokland and Niederweis show that proteins EsxE and EsxF form membrane-spanning hetero-oligomeric pores that are important for TNT secretion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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