Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Clémence Mooser; Ioanna-Eleni Symeonidou; Pia-Amata Leimbacher; Alison Ribeiro; Ann-Marie K. Shorrocks; Stephanie Jungmichel; Sara C. Larsen; Katja Knechtle; Arti Jasrotia; Diana Zurbriggen; Alain Jeanrenaud; Colin Leikauf; Daniel Fink; Michael L. Nielsen; Andrew N. Blackford; Manuel Stucki

doi:10.1038/s41467-019-13981-x

Nature Communications (Jan 2020)

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Clémence Mooser,
Ioanna-Eleni Symeonidou,
Pia-Amata Leimbacher,
Alison Ribeiro,
Ann-Marie K. Shorrocks,
Stephanie Jungmichel,
Sara C. Larsen,
Katja Knechtle,
Arti Jasrotia,
Diana Zurbriggen,
Alain Jeanrenaud,
Colin Leikauf,
Daniel Fink,
Michael L. Nielsen,
Andrew N. Blackford,
Manuel Stucki

Affiliations

Clémence Mooser: Department of Gynecology, University of Zurich
Ioanna-Eleni Symeonidou: Department of Gynecology, University of Zurich
Pia-Amata Leimbacher: Department of Gynecology, University of Zurich
Alison Ribeiro: Department of Gynecology, University of Zurich
Ann-Marie K. Shorrocks: Department of Oncology, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
Stephanie Jungmichel: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
Sara C. Larsen: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
Katja Knechtle: Department of Gynecology, University of Zurich
Arti Jasrotia: Department of Gynecology, University of Zurich
Diana Zurbriggen: Department of Gynecology, University of Zurich
Alain Jeanrenaud: Department of Gynecology, University of Zurich
Colin Leikauf: Department of Gynecology, University of Zurich
Daniel Fink: Department of Gynecology, University of Zurich
Michael L. Nielsen: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
Andrew N. Blackford: Department of Oncology, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
Manuel Stucki: Department of Gynecology, University of Zurich

DOI: https://doi.org/10.1038/s41467-019-13981-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar segregation in response to rDNA breaks.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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