An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

Mitsuo Kato; Mei Wang; Zhuo Chen; Kirti Bhatt; Hyung Jung Oh; Linda Lanting; Supriya Deshpande; Ye Jia; Jennifer Y.C. Lai; Christopher L. O’Connor; YiFan Wu; Jeffrey B. Hodgin; Robert G. Nelson; Markus Bitzer; Rama Natarajan

doi:10.1038/ncomms12864

Nature Communications (Sep 2016)

An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

Mitsuo Kato,
Mei Wang,
Zhuo Chen,
Kirti Bhatt,
Hyung Jung Oh,
Linda Lanting,
Supriya Deshpande,
Ye Jia,
Jennifer Y.C. Lai,
Christopher L. O’Connor,
YiFan Wu,
Jeffrey B. Hodgin,
Robert G. Nelson,
Markus Bitzer,
Rama Natarajan

Affiliations

Mitsuo Kato: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Mei Wang: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Zhuo Chen: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Kirti Bhatt: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Hyung Jung Oh: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Linda Lanting: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Supriya Deshpande: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Ye Jia: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Jennifer Y.C. Lai: Department of Internal Medicine, University of Michigan
Christopher L. O’Connor: Department of Internal Medicine, University of Michigan
YiFan Wu: Department of Internal Medicine, University of Michigan
Jeffrey B. Hodgin: Department of Pathology, University of Michigan
Robert G. Nelson: Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Markus Bitzer: Department of Internal Medicine, University of Michigan
Rama Natarajan: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope

DOI: https://doi.org/10.1038/ncomms12864
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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Nephropathy is a common and hard-to-treat consequence of diabetes. Here Kato et al. show that a megacluster of microRNAs regulates early development of diabetic nephropathy in mice, and that inhibition of the cluster's host long non-coding RNA transcript attenuates disease symptoms, suggesting a new therapy for diabetic nephropathy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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