Respirology Case Reports (Dec 2021)

Robust response of pulmonary pleomorphic carcinoma to pembrolizumab and sequential radiotherapy: A case report

  • Tae‐Hun Kim,
  • Sun Hyo Park,
  • Ilseon Hwang,
  • Jin Hee Lee,
  • Jin Hee Kim,
  • Hae Won Kim,
  • Hyun Jung Kim

DOI
https://doi.org/10.1002/rcr2.875
Journal volume & issue
Vol. 9, no. 12
pp. n/a – n/a

Abstract

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Abstract Pulmonary pleomorphic carcinoma (PPC) is a rare type of non‐small cell lung cancer (NSCLC) with a more aggressive clinical course and a worse outcome than other types of NSCLC. Pembrolizumab, a monoclonal antibody targeting programmed cell death‐1 (PD‐1), has been approved as the first‐line treatment for advanced NSCLC with robust PD‐L1 expression in at least 50% of tumour cells, without epidermal growth factor receptor gene (EGFR) mutations or anaplastic lymphoma kinase gene (ALK) rearrangement. Here, we report the case of an 81‐year‐old man with multiple comorbidities who was diagnosed with PPC and showed a robust response to pembrolizumab followed by radiation therapy without adverse effects. In the absence of randomized clinical trials for PPCs, our case report demonstrates the potential application of pembrolizumab and radiation therapy for the treatment of PPCs.

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