Journal of Mazandaran University of Medical Sciences (Nov 2023)
Cardio Protective Effects of Propofol against Ischemic/Reperfusion Injury following Coronary Artery Bypass Graft (CABG)
Abstract
Background and purpose: Despite cardioprotective strategies against ischemia/reperfusion injury following coronary artery bypass graft (CABG), its complications still exist. Therefore, the present study aimed to determine the cardioprotective effects of propofol against ischemic/reperfusion injury following CABG. Materials and methods: In this double-blind clinical trial study, 70 patients undergoing CABG were admitted to Fatemeh Zahra Hospital, Sari, Iran, 2017 were evaluated. The participants were divided into two groups of the anesthetic induction group with the combination of propofol, midazolam, fentanyl, and ether and the anesthetic induction group with nesdonal, midazolam, fentanyl, and ether. The data were registered in the checklist made by the researcher. The data were analyzed by SPSS software using descriptive and analytical statistical tests. Results: An increase in the level of creatinine and C-reactive protein was observed in both study groups from the time of opening the aortic clamp until 15 min after, and a decrease in the ventricular ejection fraction from before surgery to 48 h post-surgery(P<0.05). An increase in troponin level was reported only in the anesthetic induction group with propofol, midazolam, fentanyl, and ether (P=0.04). Conclusion: Considering the increased levels of creatinine, troponin, serum C-reactive protein, and the decrease in ventricular ejection fraction in the propofol combination group, this drug is not superior in reducing ischemia/reperfusion injury compared to the nasedonal combination.
