International Journal of Nanomedicine (Sep 2022)
Role of Exosomes in Pharyngucutaneous Fistula After Total Laryngectomy
Abstract
Li Chen,1,* Maohua Wang,2,* Zhenhua Zhong,3,* Baoxu Liu,1 Wentao Zhang,4 Bin Zhu,4 Cheng Jiao,4 Chenjie Yu,5 Bing Guan4 1Department of Otolaryngology, Head and Neck Surgery, Dalian Medical University, Dalian, 116000, People’s Republic of China; 2Department of Otolaryngology, Head and Neck Surgery, The First People’s Hospital of Foshan, Foshan, 528000, People’s Republic of China; 3Department of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, People’s Republic of China; 4Department of Otolaryngology, Head and Neck Surgery, Clinical Medical College, Yangzhou University, Yangzhou, 225001, People’s Republic of China; 5Department of Otolaryngology, Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, 210008, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chenjie Yu, Department of Otolaryngology, Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, 210008, People’s Republic of China, Tel/Fax +86-13705168089, Email [email protected] Bing Guan, Department of Otolaryngology, Head and Neck Surgery, Clinical Medical College, Yangzhou University, Yangzhou, 225001, People’s Republic of China, Tel/Fax +86-18051063666, Email [email protected]: Pharyngocutaneous fistula is the most common complication after total laryngectomy and is difficult to heal. Although conservative treatment and surgical repair are effective, they often take longer and additional trips to the operating room, which undoubtedly increases the financial burden on patients. Especially in combination with diseases such as diabetes and hypertension, which affect the efficacy of surgery. Adding growth factors into the repair material can promote fibroblast proliferation, angiogenesis, and accelerate wound healing. A substantial number of studies have shown that a type of nanoscale extracellular vesicle, called exosomes, facilitates organization repair by promoting blood vessel production, protein polysaccharides, and collagen deposition, thereby representing a new type of cellular therapy. At present, there is little research on the application of exosomes in pharyngocutaneous fistula regeneration after total laryngectomy. In this review, we summarize the biological characteristics of exosomes and their application in biomedical science, and highlight their application prospects in pharyngocutaneous fistula regeneration after total laryngectomy.Keywords: exosomes, extracellular vesicle, head and neck squamous cell carcinoma, pharyngocutaneous fistula, tissue repair and regeneration, bioengineering
