Nature Communications (Jul 2021)
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
- Wulf Tonnus,
- Claudia Meyer,
- Christian Steinebach,
- Alexia Belavgeni,
- Anne von Mässenhausen,
- Nadia Zamora Gonzalez,
- Francesca Maremonti,
- Florian Gembardt,
- Nina Himmerkus,
- Markus Latk,
- Sophie Locke,
- Julian Marschner,
- Wenjun Li,
- Spencer Short,
- Sebastian Doll,
- Irina Ingold,
- Bettina Proneth,
- Christoph Daniel,
- Nazanin Kabgani,
- Rafael Kramann,
- Stephen Motika,
- Paul J. Hergenrother,
- Stefan R. Bornstein,
- Christian Hugo,
- Jan Ulrich Becker,
- Kerstin Amann,
- Hans-Joachim Anders,
- Daniel Kreisel,
- Derek Pratt,
- Michael Gütschow,
- Marcus Conrad,
- Andreas Linkermann
Affiliations
- Wulf Tonnus
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Claudia Meyer
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Christian Steinebach
- Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn
- Alexia Belavgeni
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Anne von Mässenhausen
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Nadia Zamora Gonzalez
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Francesca Maremonti
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Florian Gembardt
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Nina Himmerkus
- Institute of Physiology, Christian-Albrecht-University Kiel
- Markus Latk
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Sophie Locke
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Julian Marschner
- Division of Nephrology, Department of Medicine IV, University Hospital LMU Munich
- Wenjun Li
- Department of Surgery, Washington University
- Spencer Short
- Department of Chemistry and Biomolecular Sciences, University of Ottawa
- Sebastian Doll
- Institute of Metabolism and Cell Death, Helmholtz Zentrum München
- Irina Ingold
- Institute of Metabolism and Cell Death, Helmholtz Zentrum München
- Bettina Proneth
- Institute of Metabolism and Cell Death, Helmholtz Zentrum München
- Christoph Daniel
- Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg
- Nazanin Kabgani
- Clinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Disease, University Hospital of the RWTH Aachen
- Rafael Kramann
- Clinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Disease, University Hospital of the RWTH Aachen
- Stephen Motika
- Department of Pathobiology, University of Illinois
- Paul J. Hergenrother
- Department of Pathobiology, University of Illinois
- Stefan R. Bornstein
- Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Christian Hugo
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- Jan Ulrich Becker
- Institute of Pathology, University Hospital of Cologne
- Kerstin Amann
- Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg
- Hans-Joachim Anders
- Division of Nephrology, Department of Medicine IV, University Hospital LMU Munich
- Daniel Kreisel
- Department of Surgery, Washington University
- Derek Pratt
- Department of Chemistry and Biomolecular Sciences, University of Ottawa
- Michael Gütschow
- Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn
- Marcus Conrad
- Institute of Metabolism and Cell Death, Helmholtz Zentrum München
- Andreas Linkermann
- Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden
- DOI
- https://doi.org/10.1038/s41467-021-24712-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Necroptosis, a form of cell death, occurs in acute renal injury. Here, the authors show that ferroptosis—a form of cell death dependent on iron - also occurs during acute kidney injury, and show that an inhibitor of ferroptosis can improve survival in a mouse model of acute kidney damage.
