Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease

Alex Kayongo; Alex Kayongo; Alex Kayongo; Brian Nyiro; Brian Nyiro; Trishul Siddharthan; Bruce Kirenga; William Checkley; William Checkley; Moses Lutaakome Joloba; Jerrold Ellner; Padmini Salgame

doi:10.3389/fcimb.2023.1146571

Frontiers in Cellular and Infection Microbiology (Jun 2023)

Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease

Alex Kayongo,
Alex Kayongo,
Alex Kayongo,
Brian Nyiro,
Brian Nyiro,
Trishul Siddharthan,
Bruce Kirenga,
William Checkley,
William Checkley,
Moses Lutaakome Joloba,
Jerrold Ellner,
Padmini Salgame

Affiliations

Alex Kayongo: Department of Medicine, Center for Emerging Pathogens, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States
Alex Kayongo: Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda
Alex Kayongo: Makerere University College of Health Sciences, Lung Institute, Makerere University, Kampala, Uganda
Brian Nyiro: Department of Medicine, Center for Emerging Pathogens, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States
Brian Nyiro: Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda
Trishul Siddharthan: Division of Pulmonary and Critical Care Medicine, University of Miami, Miami, FL, United States
Bruce Kirenga: Makerere University College of Health Sciences, Lung Institute, Makerere University, Kampala, Uganda
William Checkley: Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States
William Checkley: Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, United States
Moses Lutaakome Joloba: Makerere University College of Health Sciences, Lung Institute, Makerere University, Kampala, Uganda
Jerrold Ellner: Department of Medicine, Center for Emerging Pathogens, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States
Padmini Salgame: Department of Medicine, Center for Emerging Pathogens, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States

DOI: https://doi.org/10.3389/fcimb.2023.1146571
Journal volume & issue: Vol. 13

Abstract

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Pulmonary tuberculosis is increasingly recognized as a risk factor for COPD. Severe lung function impairment has been reported in post-TB patients. Despite increasing evidence to support the association between TB and COPD, only a few studies describe the immunological basis of COPD among TB patients following successful treatment completion. In this review, we draw on well-elaborated Mycobacterium tuberculosis-induced immune mechanisms in the lungs to highlight shared mechanisms for COPD pathogenesis in the setting of tuberculosis disease. We further examine how such mechanisms could be exploited to guide COPD therapeutics.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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