Proton Magnetic Resonance Spectroscopy in Brain Science Researches

Abstract

Nuclear magnetic resonance spectroscopy, especially in vivo proton magnetic resonance spectrum (1H MRS) and proton nuclear magnetic resonance (1H NMR), has been increasingly used in brain science researches. There are pros and cons in 1H MRS and 1H NMR with respect to experiment design, sample preparation and data processing. In this review, we summarized and discussed the recent progresses of these two techniques in the ends of application range, sample preparation, quantification and data analysis. The work will provide a reference and insights for neuroscience researchers who are interested in using magnetic resonance spectroscopy for metabolic studies of the brain.

Keywords

• nuclear magnetic resonance spectroscopy
• in vivo spectrum
• brain science
• metabolism