Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature

Jia Li; Yu-An Li; Ge Wu; Xu Zhang

doi:10.3389/fchem.2022.917371

Frontiers in Chemistry (May 2022)

Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature

Jia Li,
Yu-An Li,
Ge Wu,
Xu Zhang

Affiliations

Jia Li: Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Yu-An Li: Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
Ge Wu: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
Xu Zhang: Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

DOI: https://doi.org/10.3389/fchem.2022.917371
Journal volume & issue: Vol. 10

Abstract

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A simple and practical strategy for intermolecular aminohalogenation of quinone with alkyl amines and NXS was developed, in which haloamines generated in situ were employed as bifunctional reagents. The reaction system is reliable, efficient and wide in substrate range, which is suitable for the two-fold aminochlorination of 1, 4-benzoquinones, large-scale reaction and late-stage modification of pharmaceuticals.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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Abstract

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