Pulmonary Circulation (Dec 2017)

Identity crisis in pulmonary arterial hypertension

  • G. Ruffenach,
  • S. Bonnet,
  • S. Rousseaux,
  • S. Khochbin,
  • S. Provencher,
  • F. Perros

DOI
https://doi.org/10.1177/2045893217746054
Journal volume & issue
Vol. 8

Abstract

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Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes.