Relationship between Indel Variants within the <i>JAK2</i> Gene and Growth Traits in Goats
Xian-Feng Wu,
Qian Xu,
Ao Wang,
Ben-Zhi Wang,
Xian-Yong Lan,
Wen-Yang Li,
Yuan Liu
Affiliations
Xian-Feng Wu
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou 350013, China
Qian Xu
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou 350013, China
Ao Wang
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Ben-Zhi Wang
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Xian-Yong Lan
Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China
Wen-Yang Li
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou 350013, China
Yuan Liu
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou 350013, China
Janus kinase 2 (JAK2) plays a critical role in myoblast proliferation and fat deposition in animals. Our previous RNA-Seq analyses identified a close association between the JAK2 gene and muscle development. To date, research delving into the relationship between the JAK2 gene and growth traits has been sparse. In this study, we sought to investigate the relationship between novel mutations within the JAK2 gene and goat growth traits. Herein, two novel InDel (Insertion/Deletion) polymorphisms within the JAK2 gene were detected in 548 goats, and only two genotypes were designated as ID (Insertion/Deletion) and DD (Deletion/Deletion). The results indicate that the two InDels, the del19008 locus in intron 2 and del72416 InDel in intron 6, showed significant associations with growth traits (p JAK2 gene could serve as valuable molecular markers for enhancing goat growth traits in breeding programs.
