Anti-tumor necrosis factor-induced palmoplantar psoriasis: Case series

Abstract

Palmoplantar pustular psoriasis (PPP) is a very uncommon form of psoriasis. Patients usually present with sterile, intraepidermal pustules over palms and soles, and it is difficult to treat. Women and smokers may be at a higher risk of getting PPP. Here, we report 2 patients who developed new PPP lesions after initiation of adalimumab (Humira®). Case reports are for a 19-year-old female diagnosed with Crohn's disease on February 2012 after a long history of abdominal pain and bleeding and a 34-year-old female who had psoriatic arthritis with no skin lesions since November 2012. Our recommendation is for the patients to be controlled with potent topical corticosteroids, keratolytics, Vitamin D analogs, phototherapy, increases in baseline methotrexate doses, and cyclosporine as needed.

Keywords

• adalimumab
• crohn's disease
• palmoplantar psoriasis