Nature and Science of Sleep (Nov 2023)
Bidirectional Relationship Between Circadian Rhythm and Frailty
Abstract
Yu Pan,* Zhu Qing Feng,* Yan Yuan,* Gui Ming Hu, Yi Jiang, Jiang Chuan Dong Department of Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China*This authors Contributed equally to this workCorrespondence: Jiang Chuan Dong, Department of Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Road, Yuzhong District, Chongqing, 400010, People’s Republic of China, Email [email protected]: Coupled with the ageing population, frailty, characterized by high prevalence and difficult treatment, has progressively evolved into a significant public health concern. Frail individuals can often observe serious metabolic disorders and sleep-wake cycle disruption, which may be caused by the decline in physiological reserve and increased vulnerability. Moreover, sleep-wake cycle disruptions and metabolic dysfunctions associated with circadian rhythm disorders are considered to be a central part of the disorder. Previous studies have documented a correlation between frailty and sleep-wake disruptions; nevertheless, the association between circadian rhythm disorders and frailty has not yet been definitively established. Hence, we hypothesize a bidirectional link between circadian rhythm disorders and frailty, with each condition exerting a significant influence on the progression of the other’s disease trajectory.Keywords: circadian rhythm, frailty, metabolism, neuropathy, insulin resistance
