Effects of Immune Cells and Cytokines on Different Cells in OA

Abstract

Pan Luo,* Qiling Yuan,* Xianjie Wan, Mingyi Yang, Peng Xu Department of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China*These authors contributed equally to this workCorrespondence: Peng Xu, Department of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an, Shanxi, People’s Republic of China, Email [email protected]: The pathological manifestations of osteoarthritis (OA) involve the destruction of articular cartilage, synovial sac thickening, subchondral osteosclerosis and osteophyte formation. The types of cells involved in OA include chondrocytes, osteoblasts, osteoclasts, synovial fibroblasts, T cells, macrophages, and mesenchymal stem cells (MSCs). There are many effects of immune cells in OA, and innate immune cells such as dendritic cells and macrophages have significant roles in the pathogenesis of OA. On the other hand, the role of adaptive immune cells such as T-cell subsets, B-cell subsets, and NK cells is important in OA pathogenesis. MSCs not only play a key role in the dynamic balance and repair of OA tissue but also inhibit the immune system. Therefore, MSCs are a new potential therapeutic agent for OA. This review mainly summarizes the effects of various immune cells and cytokines on different cells in OA to find new effective therapeutic targets for OA therapy based on the immune system and cytokine activity sites to prevent the development of OA.Keywords: osteoarthritis, immune cells, chondrocytes, mesenchymal stem cells, osteoblasts

Keywords

• osteoarthritis
• immune cells
• chondrocytes
• mesenchymal stem cells
• osteoblasts