Сахарный диабет (Mar 2015)

Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets

  • Ivan Nikolaevich Tyurenkov,
  • Denis Vladimirovich Kurkin,
  • Elena Vladimirovna Volotova,
  • Dmitriy Alexandrovich Bakulin,
  • Elena Michailovna Lomkina

DOI
https://doi.org/10.14341/DM20151101-109
Journal volume & issue
Vol. 18, no. 1
pp. 101 – 109

Abstract

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In this review we discuss ten promising biological targets of interest for treating type 2 diabetes mellitus, obesity and metabolic syndrome. Namely, we address current experimental and clinical data on several new compounds that affect SGLT2, 11b-HSD1, PTP1B, SCD1, Il-1?. , fructose-1,6-bisphosphatase, glycogen phosphorylase, SIRT1, DGAT-1 and GPR119. The body of data shows potential of these substances to become effective antidiabetic agents.

Keywords