Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation

Abstract

C–H activations and hydroaminations are useful synthetic procedures for building up complex, functional molecules. Here, the authors report a single catalyst capable of performing tandem C–H activation and hydroamination, giving access to N-heterocycles via the [4+2] annulation of aromatic imines and alkynes.