Clinical, Cosmetic and Investigational Dermatology (Apr 2023)
Verrucous Granular Parakeratosis on the Groin: A Case Report
Abstract
Huixian Li,1 Hui Li,2 Qinghua Tian,2 Xiangang Fang2 1Department of Sterilization Supply, Weifang People’s Hospital, Weifang, Shandong, People’s Republic of China; 2Department of Dermatology, Weifang People’s Hospital, Weifang, Shandong, People’s Republic of ChinaCorrespondence: Xiangang Fang, Department of Dermatology, Weifang People’s Hospital, 151 Guangwen Street, Weifang, Shandong, 261041, People’s Republic of China, Tel +86-536-8192561, Email [email protected]: Granular parakeratosis is a rare dermatosis characterized by erythematous scaly patches or papules, and plaques, often involving intertriginous areas. In this work, a 73-year-old Chinese male patient presented with a 6-month history of pruritic verrucous papules on the bilateral groin. A skin biopsy was performed and revealed the following: the horny layer showed highly compact hyperkeratosis and parakeratosis with basophilic granules; the epidermis showed obvious acanthosis with psoriasiform hyperplasia. The final diagnosis was verrucous granular parakeratosis. We also reviewed the progress in nomenclature, etiology, clinical manifestations, differential diagnosis and treatment. Different clinical manifestations may represent different clinical entities. Dermatologists should differentiate it from other diseases to make a correct diagnosis. Treatment options should be based on the variable etiologies and clinical manifestations.Keywords: granular parakeratosis, verrucous, papule, groin, glucocorticoid, tretinoin
