Nature Communications (Feb 2017)

Compiler-aided systematic construction of large-scale DNA strand displacement circuits using unpurified components

  • Anupama J. Thubagere,
  • Chris Thachuk,
  • Joseph Berleant,
  • Robert F. Johnson,
  • Diana A. Ardelean,
  • Kevin M. Cherry,
  • Lulu Qian

DOI
https://doi.org/10.1038/ncomms14373
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

DNA circuits hold promise for advancing information-based molecular technologies, yet it is challenging to design and construct them in practice. Thubagereet al. build DNA strand displacement circuits using unpurified strands whose sequences are automatically generated from a user-friendly compiler.