The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction

Ahmad Luqman-Fatah; Yuzo Watanabe; Kazuko Uno; Fuyuki Ishikawa; John V. Moran; Tomoichiro Miyoshi

doi:10.1038/s41467-022-35757-6

Nature Communications (Jan 2023)

The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction

Ahmad Luqman-Fatah,
Yuzo Watanabe,
Kazuko Uno,
Fuyuki Ishikawa,
John V. Moran,
Tomoichiro Miyoshi

Affiliations

Ahmad Luqman-Fatah: Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University
Yuzo Watanabe: Proteomics Facility, Graduate School of Biostudies, Kyoto University
Kazuko Uno: Division of Basic Research, Louis Pasteur Center for Medical Research
Fuyuki Ishikawa: Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University
John V. Moran: Department of Human Genetics, University of Michigan Medical School
Tomoichiro Miyoshi: Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University

DOI: https://doi.org/10.1038/s41467-022-35757-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 26

Abstract

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Proteomic analyses revealed that a group of interferon-stimulated genes suppresses LINE-1 retrotransposon activities, including HELZ2, which reduces LINE-1 RNA and the associated innate immune response levels.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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