Investigation of an Active Measurement Method to Detect Inertial Cavitation and the Presence of Potential Drug Carriers

Abstract

Drug carriers, such as nanoparticles, are capable of releasing pharmaceutically active ingredients, which can be initiated by focused ultrasound via the effect of inertial cavitation. This effect of inertial cavitation is often verified by passive measurement methods that rely on the analysis of emitted acoustic signals caused by the implosion of bubbles. However, a major issue of such methods is their inability to detect the presence of potential drugs in human vessels, complicating the implementation of a closed loop control for future medical therapies. Therefore, this contribution introduces an active measurement method to determine both inertial cavitation and the presence of potential drug carriers in a tissue mimicking phantom

Keywords

• active cavitation detection
• fus
• inertial cavitation
• drug delivery