Cystatin C Level in Prediabetic and Diabetic Patients

Abstract

INTRODUCTION[|]Cystatin C is a novel marker of kidney function, considered to be more accurate than creatinine. Serum Cystatin C has been shown to correlate with the progression of pre-diabetes and type 2 diabetes mellitus. The aim of this study was to evaluate cystatin C levels in diabetic and pre-diabetic patients and determine its association with anthropometric measurements and insulin resistance. [¤]METHODS[|]Twenty-five patients with diabetes, 17 patients with pre-diabetes and 24 healthy controls were included in the study. None of the patients had any diabetic complications.[¤]RESULTS[|]Diabetic patients had higher body mass index (BMI) than controls (p=0.01). Serum cystatin C levels were similar between the three groups (p>0.05). Sex and/or smoking had no effect on cystatin levels. Higher cystatin C levels were negatively associated with microalbuminuria. Cystatin C levels were correlated with BMI and HOMA-IR in pre-diabetic patients (p=0.039 and P<0. 05, respectively) but not in diabetic patients or controls, when adjusted for age and gender. [¤]DISCUSSION AND CONCLUSION[|]Serum cystatin C levels are associated with BMI and insulin resistance in pre-diabetic patients. These results suggest that higher BMI levels are associated with high cystatin C levels, which is predictive of future risk of diabetes mellitus.[¤]

Keywords

• cystatin c
• diabetes mellitus
• prediabetes.