The 2016 WHO Classification of Tumors of the Central Nervous System: the experience of new classifications

Abstract

Central nervous system tumors are common tumors encountered by neurosurgeons. With the development of molecular genetics, molecular genetic characteristics are applied to the 2016 World Health Organization (WHO) Classification of Tumors of the Central Nervous System and tumor classification was updated combined the histological and molecular genetic characteristics of tumors. According to isocitrate dehydrogenase (IDH) gene mutation and 1p/19q codeletion, new lassifications of gliomas are defined. RELA fusion?positive ependymoma is defined according to RELA gene fusion. Embryonal tumors, especially medulloblastoma increased the diagnosis of molecular typing. Combining the characteristics of tumor molecular genetics is helpful for clinicians to understand the development and progression, and improve the treatment of tumors, but we still can not ignore the basic role of histology. DOI: 10.3969/j.issn.1672-6731.2018.05.002

Keywords

• Central nervous system neoplasms
• World Health Organization
• Immunohistochemistry
• Genetics
• Molecular biology
• Pathology
• Review