Neuropilin-1 Expression in Treg and PDC Cells in Peripheral Blood of Non-small Cell Lung Cancer Patients and Clinical Significance

Abstract

Objective To investigate Neuropilin-1 expression in Treg and PDC cells in peripheral blood of non-small cell lung cancer patients and clinical significance. Methods We collected the peripheral blood of 49 diagnosed non-small cell lung cancer patients, and 33 healthy subjects were taken as control group. The expression of NRP-1 on Treg and PDC cells in peripheral blood were detected by flow cytometry. Results The expression rate of NRP-1 in Treg cells of NSCLC patients was significantly higher than that of healthy subjects (P < 0.05). The expression of NRP-1 in Treg cells of NSCLC patients was correlated with the maximum diameter of tumor, lymph node metastasis, TNM stage and differentiation degree (P < 0.05); the expression of PDC was related to the maximum diameter of the tumor, lymph node metastasis and TNM staging(P < 0.05). Conclusion The expression of NRP-1 in peripheral blood Treg and PDC cells may be associated with immunoregulation of non-small cell lung cancer. It may be a tumor marker for predicting the prognosis of NSCLC patients, and a new target for lung cancer treatment.

Keywords

• non-small cell lung cancer(nsclc)
• neuropilin-1(nrp-1)
• treg
• pdc
• flow cytology