Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and health care
Huan Zhang,
Bing Jun Yang Lee,
Tong Wang,
Xuesong Xiang,
Yafang Tan,
Yanping Han,
Yujing Bi,
Fachao Zhi,
Xin Wang,
Fang He,
Seppo J. Salminen,
Baoli Zhu,
Ruifu Yang
Affiliations
Huan Zhang
School of Public Health, Hebei Medical University, Hebei, China; State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China
Bing Jun Yang Lee
Hong Kong Yanstone Preventive Science Co., Limited, Hong Kong, China
Tong Wang
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China
Xuesong Xiang
National Institute of Nutrition and Health, China Center for Disease Control, Beijing, China
Yafang Tan
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China
Yanping Han
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China
Yujing Bi
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China
Fachao Zhi
Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangdong, China
Xin Wang
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products & Food Sciences Institute, Zhejiang Academy of Agricultural Sciences, Zhejiang, China
Fang He
West China School of Public Health and West China Fourth Hospital and Healthy Food Evaluation Research Center, Sichuan University, Sichuan, China
Seppo J. Salminen
Functional Foods Forum, Faculty of Medicine, Itäinen Pitkäkatu 4A, FI-20014, University of Turku, Southwest Finland, Finland; Correspondence:
Baoli Zhu
Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Correspondence:
Ruifu Yang
School of Public Health, Hebei Medical University, Hebei, China; State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China; Correspondence:
The terms “inflammatome” (holistic inflammation networks) and “inflammatomics” (a novel omics field) were proposed to decode dysbiosis-driven chronic inflammation and its disease links. Inflammatomics explores microbiota–immune crosstalk, particularly innate immune interactions, revealing how dysregulated microbial communities trigger chronic inflammation underlying disorders like inflammatory bowel disease, metabolic diseases, and neurodegeneration. This discipline transcends traditional inflammation paradigms by dissecting molecular pathways connecting dysbiosis to systemic inflammation, enabling early detection and precision interventions. It integrates evolutionary perspectives on host–microbe interactions, emphasizing the human body as a stress-sensitive “organ”. Challenges include standardizing inflammatome profiling, translating findings into clinical tools, and advancing multiomics technologies. By bridging microbial ecology, immunology, and systems medicine, inflammatomics holds a transformative potential to shift health care from reactive treatment to proactive, personalized prevention, targeting disease origins shaped by chronic inflammatome dysregulation.
