Japanese giant benign prostatic hyperplasia: Sibling cases

Abstract

Introduction The pathophysiology of benign prostatic hyperplasia (BPH) remains incompletely understood but is likely multifactorial. Inflammation and metabolic factors may increase the risk of BPH. Several studies have evaluated the possible roles played by genetic factors. Here, we describe two cases of suspected familial BPH. Case presentations We report the cases of two brothers, aged 77 and 69 years, with giant BPH. As both exhibited urinary retention, we performed Holmium Laser Enucleation of the Prostate (HoLEP) and obtained tissue samples weighing 276 g and 153 g, respectively. The postoperative courses were good. Conclusion We experienced two cases of sibling BPH with volumes exceeding 200 mL and successfully treated them with HoLEP.

Keywords

• family history
• giant benign prostatic hyperplasia
• holmium laser enucleation of the prostate