Nature Communications (Aug 2017)
HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
- Wen-Fang Wang,
- Li Yan,
- Zhao Liu,
- Lan-Xuan Liu,
- Jian Lin,
- Zhi-Yin Liu,
- Xiong-Ping Chen,
- Wu Zhang,
- Zi-Zhen Xu,
- Ting Shi,
- Jun-Min Li,
- Yi-Lei Zhao,
- Guoyu Meng,
- Yi Xia,
- Jian-Yong Li,
- Jiang Zhu
Affiliations
- Wen-Fang Wang
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Li Yan
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Zhao Liu
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Lan-Xuan Liu
- State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Science, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Jian Lin
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Zhi-Yin Liu
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Xiong-Ping Chen
- State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Science, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Wu Zhang
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Zi-Zhen Xu
- Department of Laboratory Medicine, Rui-Jin Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University
- Ting Shi
- State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Science, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Jun-Min Li
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Yi-Lei Zhao
- State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Science, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Guoyu Meng
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Yi Xia
- The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital
- Jian-Yong Li
- The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital
- Jiang Zhu
- State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-00476-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for certain lymphomas.
