Clinical, Cosmetic and Investigational Dermatology (Oct 2021)
The Relationship Between Alzheimer’s Disease and Skin Diseases: A Review
Abstract
Hanlin Zhang,* Dingyue Zhang,* Keyun Tang,* Qiuning Sun Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Skin and Immune Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiuning Sun Tel/Fax +86-10-69156114Email [email protected]: Alzheimer’s disease is the most common type of dementia placing a heavy burden on the healthcare system worldwide. Skin diseases are also one of the most common health problems. Several skin diseases are associated with Alzheimer’s disease through different mechanisms. This review summarizes the relationship between Alzheimer’s disease and several types of skin diseases, including bullous pemphigoid, hidradenitis suppurativa, psoriasis, skin cancer, and cutaneous amyloidosis, and provides suggestions based on these associations. Neurologists, dermatologists, and general practitioners should be aware of the relationship between Alzheimer’s disease and skin diseases. Dermatology/neurology consultation or referral is necessary when needed.Keywords: Alzheimer’s disease, dementia, skin disease, bullous pemphigoid, hidradenitis suppurativa, psoriasis
