Microrheological Disorders in Critical Conditions

Abstract

The review describes the role of a change in the morphofunctional properties of red blood cells in the pathogenesis of severe concomitant injury, sepsis, and acute respiratory distress syndrome. The authors give data on the nonspecific mechanisms responsible for the provision and maintenance of oxygen transport at the microvascular level. Furthermore, the review summarizes the results of recent studies dealing with the contribution of microrheological disorders to the development of organ dysfunction in sepsis and other critical conditions. Whether microrheological disorders can be corrected is also considered. Key words: critical conditions, erythrocyte deformability, erythrocyte aggregation, perftoran, infusion therapy.