Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity
Alena Dmitrievna Khudiakova,
Yana Vladimirovna Polonskaya,
Victoria Sergeevna Shramko,
Lilia Valeryevna Shcherbakova,
Evgeniia Vitalievna Striukova,
Elena Vladimirovna Kashtanova,
Yulia Igorevna Ragino
Affiliations
Alena Dmitrievna Khudiakova
Research Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, Russia
Yana Vladimirovna Polonskaya
Research Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, Russia
Victoria Sergeevna Shramko
Research Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, Russia
Lilia Valeryevna Shcherbakova
Research Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, Russia
Evgeniia Vitalievna Striukova
Research Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, Russia
Elena Vladimirovna Kashtanova
Research Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, Russia
Yulia Igorevna Ragino
Research Institute of Internal and Preventive Medicine—Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175/1, Novosibirsk 630089, Russia
The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa.
