Divergent synthesis and identification of the cellular targets of deoxyelephantopins

Roman Lagoutte; Christelle Serba; Daniel Abegg; Dominic G. Hoch; Alexander Adibekian; Nicolas Winssinger

doi:10.1038/ncomms12470

Nature Communications (Aug 2016)

Divergent synthesis and identification of the cellular targets of deoxyelephantopins

Roman Lagoutte,
Christelle Serba,
Daniel Abegg,
Dominic G. Hoch,
Alexander Adibekian,
Nicolas Winssinger

Affiliations

Roman Lagoutte: Department of Organic Chemistry, School of Chemistry and Biochemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest-Ansermet
Christelle Serba: Department of Organic Chemistry, School of Chemistry and Biochemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest-Ansermet
Daniel Abegg: Department of Organic Chemistry, School of Chemistry and Biochemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest-Ansermet
Dominic G. Hoch: Department of Organic Chemistry, School of Chemistry and Biochemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest-Ansermet
Alexander Adibekian: Department of Organic Chemistry, School of Chemistry and Biochemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest-Ansermet
Nicolas Winssinger: Department of Organic Chemistry, School of Chemistry and Biochemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest-Ansermet

DOI: https://doi.org/10.1038/ncomms12470
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Deoxyelephantopin is a naturally occurring sesquiterpene lactone with known anticancer properties. Here, the authors synthesize deoxyelephantopins and a range of analogues including alkyne-tagged probes, using them to identify its cellular targets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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