Genomic RNA folding mediates assembly of human parechovirus

Shabih Shakeel; Eric C. Dykeman; Simon J. White; Ari Ora; Joseph J.B. Cockburn; Sarah J. Butcher; Peter G. Stockley; Reidun Twarock

doi:10.1038/s41467-016-0011-z

Nature Communications (Feb 2017)

Genomic RNA folding mediates assembly of human parechovirus

Shabih Shakeel,
Eric C. Dykeman,
Simon J. White,
Ari Ora,
Joseph J.B. Cockburn,
Sarah J. Butcher,
Peter G. Stockley,
Reidun Twarock

Affiliations

Shabih Shakeel: Institute of Biotechnology and Department of Biosciences, University of Helsinki
Eric C. Dykeman: Departments of Mathematics and Biology and York Centre for Complex Systems Analysis, University of York
Simon J. White: Astbury Centre for Structural Molecular Biology, University of Leeds
Ari Ora: Institute of Biotechnology and Department of Biosciences, University of Helsinki
Joseph J.B. Cockburn: Astbury Centre for Structural Molecular Biology, University of Leeds
Sarah J. Butcher: Institute of Biotechnology and Department of Biosciences, University of Helsinki
Peter G. Stockley: Astbury Centre for Structural Molecular Biology, University of Leeds
Reidun Twarock: Departments of Mathematics and Biology and York Centre for Complex Systems Analysis, University of York

DOI: https://doi.org/10.1038/s41467-016-0011-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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