Frontiers in Oncology (Mar 2022)

Case Report: Adjuvant Crizotinib Therapy Exerted Favorable Survival Benefit in a Resectable Stage IIIA NSCLC Patient With Novel LDLR–ROS1 Fusion

  • An-guo Chen,
  • Dong-sheng Chen,
  • Dong-sheng Chen,
  • Dong-sheng Chen,
  • Si Li,
  • Si Li,
  • Si Li,
  • Le-le Zhao,
  • Le-le Zhao,
  • Le-le Zhao,
  • Ming-zhe Xiao,
  • Ming-zhe Xiao,
  • Ming-zhe Xiao

DOI
https://doi.org/10.3389/fonc.2022.837219
Journal volume & issue
Vol. 12

Abstract

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Novel adjuvant strategies are needed to optimize outcomes after complete surgical resection in patients with early-stage non-small-cell lung cancer (NSCLC). The adjuvant treatment of ROS Proto-Oncogene 1 (ROS1) fusion-positive resected NSCLC is challenging because there is no curative confirmed randomized controlled trial. Next-generation sequencing (NGS) and immunohistochemistry (IHC) staining were performed on the biopsy sample. In this case, we identified a novel LDLR–ROS1 fusion in a resectable stage IIIA NSCLC patient. The patient received crizotinib as adjuvant treatment and achieved recurrence-free survival (RFS) for 29 months, without significant symptoms of toxicity. In this case, we report a novel LDLR–ROS1 fusion responding to crizotinib in a patient with lung adenocarcinoma, supporting the use of adjuvant treatment with the ROS1 inhibitor exerting clinical survival benefit in ROS1 fusion-positive resected NSCLC.

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