Effects of Magnolia officinalis extract on the growth performance and immune function of weaned piglets

Abstract

Abstract Background Magnolia officinalis is a medicinal herb known for its pharmacological properties and as a potential natural feed additive. We aimed to assess the effects of dietary Magnolia officinalis extract (MOE) on the growth performance and immune function of piglets, and explored the potential of MOE as a natural alternative to antibiotics for piglet nutrition during weaning. Results Compared with the basal diet group (CK), the MOE diet significantly increased average daily feed intake and reduced diarrhea incidence and serum interleukin-6 (IL-6) levels. Compared with 0.1% MOE group, the 0.05% MOE group had lower diarrhea rates, eosinophils (EOS) count, EOS’ percentage, and serum interleukin-4 levels. Compared with CK, 0.05% MOE supplementation in the diet could reduce the diarrhea incidence and the thymus index by elevating the levels of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) in the serum, jejunum, and ileum. Compared with the basal diet group, 0.05% MOE supplementation upregulated the mRNA expressions of IL-10 and TGF-β1 in the jejunum and ileum (P < 0.05) and those of IL-10, interleukin-1β (IL-1β), and interferon-γ (IFN-γ) in the thymus (P < 0.05). Moreover, 0.05% MOE increased the levels of butyric, isobutyric, isovaleric, and valeric acids in the colon. Conclusions MOE supplementation could modulate the immune status of animals, lower production costs, and contribute to more sustainable and ethical pig farming practices by promoting healthier growth and reducing disease susceptibility. Our findings offer a sustainable solution to antibiotic use in animal farming, addressing concerns about antibiotic resistance and food safety. Graphical abstract

Keywords

• Magnolia officinalis extract
• Weaned piglet
• Growth performance
• Immunity function