In September 2018, China’s air quality monitoring protocol was amended from the standard conditions to actual conditions for particulate matter and to reference conditions for gaseous pollutants. Due to the amendment, the reported concentrations of the gaseous pollutants decreased by a constant rate of 8.4%, and the averages of PM2.5 (particulate matter that has an aerodynamic diameter of 2.5 microns or smaller) reported during September 2017 and August 2018 decreased by 7.9 ± 6.1% at 99% of the monitoring stations. Comparing the periods before and after the amendment, the 12-month PM2.5 concentrations at 17.2% of the stations actually increased despite appearing to decrease if the amendments were not considered. We reviewed 370 papers published in 2020 that utilized this air quality dataset, and 21% of these papers used the data before and after the amendment without explicitly stating whether or how conversions were conducted. It is urgent to widely broadcast the protocol amendment to ensure proper use of this extensively cited dataset.