Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology

Eun Young Yu; Syed S. Zahid; Sarah Aloe; Erik Falck-Pedersen; Xi Kathy Zhou; Nai-Kong V. Cheung; Neal F. Lue

doi:10.1038/s42003-021-02821-8

Communications Biology (Nov 2021)

Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology

Eun Young Yu,
Syed S. Zahid,
Sarah Aloe,
Erik Falck-Pedersen,
Xi Kathy Zhou,
Nai-Kong V. Cheung,
Neal F. Lue

Affiliations

Eun Young Yu: Department of Microbiology & Immunology, W. R. Hearst Microbiology Research Center, Weill Cornell Medicine
Syed S. Zahid: Department of Microbiology & Immunology, W. R. Hearst Microbiology Research Center, Weill Cornell Medicine
Sarah Aloe: Department of Microbiology & Immunology, W. R. Hearst Microbiology Research Center, Weill Cornell Medicine
Erik Falck-Pedersen: Department of Microbiology & Immunology, W. R. Hearst Microbiology Research Center, Weill Cornell Medicine
Xi Kathy Zhou: Department of Population Health Sciences, Weill Cornell Medicine
Nai-Kong V. Cheung: Department of Pediatrics, Memorial Sloan Kettering Cancer Center
Neal F. Lue: Department of Microbiology & Immunology, W. R. Hearst Microbiology Research Center, Weill Cornell Medicine

DOI: https://doi.org/10.1038/s42003-021-02821-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

Read online

Yu et al. identify marked differences in the telomere and immunologic profiles of neuroblastoma cell lines displaying MES and ADRN lineage characteristics. They show that pharmacologically converting ADRN into MES cells triggers associated switch in telomere/immunologic protein profiles whereas inhibiting telomerase activity in ADRN cells induces reversible conversion into MES cells.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal