Study objective. Investigate the association of polymorphisms E2/E3/E4 gene APOE, rs1800588 gene HL, rs2228314 gene SREBP2, rs2516839 gene USF1 with sudden cardiac death in the Russian population. Materials and methods. A group of sudden cardiac death (n = 379), the control group, matched by sex and age (n = 352). Results and discussion. The frequencies of genotypes E2/E3/E4 gene APOE, rs1800588 gene HL, rs2516839 gene USF1 was not found statistically significant differences between the groups. The frequencies of genotypes rs2228314 gene SREBP2 found statistically significant differences between the group of sudden cardiac death and the control group. GC genotype is conditionally protective against the development of sudden cardiac death (OR = 0.4, 95 % CI 0.3–0.6, p = 0.0). CC genotype is associated with an increased risk of sudden cardiac death in men (OR = 4.1, 95 %CI 1.8–9.0, p = 0.0). Conclusion. rs2228314 gene SREBP2 is associated with sudden cardiac death in the Russian population.
