Communications Biology (Jan 2023)

Human theca arises from ovarian stroma and is comprised of three discrete subtypes

  • Nicole Lustgarten Guahmich,
  • Limor Man,
  • Jerry Wang,
  • Laury Arazi,
  • Eleni Kallinos,
  • Ariana Topper-Kroog,
  • Gabriel Grullon,
  • Kimberly Zhang,
  • Joshua Stewart,
  • Nina Schatz-Siemers,
  • Sam H. Jones,
  • Richard Bodine,
  • Nikica Zaninovic,
  • Glenn Schattman,
  • Zev Rosenwaks,
  • Daylon James

DOI
https://doi.org/10.1038/s42003-022-04384-8
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 15

Abstract

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Phenotypic diversity of theca cells in growing follicles of the human ovary is described, with a differentiation trajectory proposed that initiates after follicle activation and results in multiple theca-cell subpopulations in antral follicles.