Nature Communications (Jun 2016)
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
- Abdellatif Benraiss,
- Su Wang,
- Stephanie Herrlinger,
- Xiaojie Li,
- Devin Chandler-Militello,
- Joseph Mauceri,
- Hayley B. Burm,
- Michael Toner,
- Mikhail Osipovitch,
- Qiwu Jim Xu,
- Fengfei Ding,
- Fushun Wang,
- Ning Kang,
- Jian Kang,
- Paul C. Curtin,
- Daniela Brunner,
- Martha S. Windrem,
- Ignacio Munoz-Sanjuan,
- Maiken Nedergaard,
- Steven A. Goldman
Affiliations
- Abdellatif Benraiss
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Su Wang
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Stephanie Herrlinger
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Xiaojie Li
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Devin Chandler-Militello
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Joseph Mauceri
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Hayley B. Burm
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Michael Toner
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Mikhail Osipovitch
- Center for Basic and Translational Neuroscience, University of Copenhagen
- Qiwu Jim Xu
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Fengfei Ding
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Fushun Wang
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Ning Kang
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Jian Kang
- Department of Anatomy and Cell Biology, New York Medical College
- Paul C. Curtin
- Psychogenics, Inc.
- Daniela Brunner
- Psychogenics, Inc.
- Martha S. Windrem
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Ignacio Munoz-Sanjuan
- CHDI Foundation and CHDI Management, Inc.
- Maiken Nedergaard
- Center for Translational Neuromedicine, University of Rochester Medical Center
- Steven A. Goldman
- Center for Translational Neuromedicine, University of Rochester Medical Center
- DOI
- https://doi.org/10.1038/ncomms11758
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The contribution of glia to Huntington's disease is unclear. The authors show that human glial progenitor cells (GPCs) expressing mutant huntingtin impair motor performance when engrafted into wild type mice, and wild type human GPCs ameliorate disease phenotypes when engrafted into an HD mouse model.
