Dengue virus co-opts innate type 2 pathways to escape early control of viral replication

Chathuranga L. Fonseka; Clare S. Hardman; Jeongmin. Woo; Randeep Singh; Janina Nahler; Jiahe Yang; Yi-Ling Chen; Achala Kamaladasa; Tehani Silva; Maryam Salimi; Nicki Gray; Tao Dong; Gathsaurie N. Malavige; Graham S. Ogg

doi:10.1038/s42003-022-03682-5

Communications Biology (Jul 2022)

Dengue virus co-opts innate type 2 pathways to escape early control of viral replication

Chathuranga L. Fonseka,
Clare S. Hardman,
Jeongmin. Woo,
Randeep Singh,
Janina Nahler,
Jiahe Yang,
Yi-Ling Chen,
Achala Kamaladasa,
Tehani Silva,
Maryam Salimi,
Nicki Gray,
Tao Dong,
Gathsaurie N. Malavige,
Graham S. Ogg

Affiliations

Chathuranga L. Fonseka: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Clare S. Hardman: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Jeongmin. Woo: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Randeep Singh: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Janina Nahler: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Jiahe Yang: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Yi-Ling Chen: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Achala Kamaladasa: Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
Tehani Silva: Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
Maryam Salimi: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Nicki Gray: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Tao Dong: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Gathsaurie N. Malavige: Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
Graham S. Ogg: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford

DOI: https://doi.org/10.1038/s42003-022-03682-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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Group 2 innate lymphoid cells are activated during acute dengue viral infection in human, downregulate type I-IFN responsive gene and protein expression through Prostaglandin D2, and are permissive for productive dengue viral infection.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal