Nature Communications (Dec 2018)
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
Abstract
Studies examining human podocytopathies have utilised 2D cultured primary or immortalised podocyte cell lines. Here, the authors demonstrate that 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids retain an improved podocyte identity in vitro facilitating disease modelling and toxicity testing.